Ontology highlight
ABSTRACT:
SUBMITTER: Poling BC
PROVIDER: S-EPMC5653404 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Poling Brigid Chiyoko BC Price Alexander M AM Luftig Micah A MA Cullen Bryan R BR
Virology 20171201
The Epstein-Barr virus (EBV) miR-BHRF1 microRNA (miRNA) cluster has been shown to facilitate B-cell transformation and promote the rapid growth of the resultant lymphoblastoid cell lines (LCLs). However, we find that expression of physiological levels of the miR-BHRF1 miRNAs in LCLs transformed with a miR-BHRF1 null mutant (∆123) fails to increase their growth rate. We demonstrate that the pri-miR-BHRF1-2 and 1-3 stem-loops are present in the 3'UTR of transcripts encoding EBNA-LP and that excisi ...[more]