Ontology highlight
ABSTRACT:
SUBMITTER: Lukasik SM
PROVIDER: S-EPMC2242466 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Lukasik Stephen M SM Cierpicki Tomasz T Borloz Matthew M Grembecka Jolanta J Everett Allen A Bushweller John H JH
Protein science : a publication of the Protein Society 20051229 2
Hepatoma Derived Growth Factor (HDGF) is an endogenous nuclear-targeted mitogen that is linked with human disease. HDGF is a member of the weakly conserved PWWP domain family. This 70-amino acid motif, originally identified from the WHSC1 gene, has been found in more than 60 eukaryotic proteins. In addition to the PWWP domain, many proteins in this class contain known chromatin remodeling domains, suggesting a role for HDGF in chromatin remodeling. We have determined the NMR structure of the HDG ...[more]