Ontology highlight
ABSTRACT:
SUBMITTER: Constantinides A
PROVIDER: S-EPMC5947696 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Constantinides Amanda A Gumpper Ryan R Severin Chelsea C Luo Ming M
Acta crystallographica. Section F, Structural biology communications 20180226 Pt 3
In the face of increasing drug resistance and the rapidly increasing necessity for practicality in clinical settings, drugs targeting different viral proteins are needed in order to control influenza A and B. A small molecule that tenaciously adheres to the PB2cap binding domain, part of the heterotrimeric RNA polymerase machinery of influenza A virus and influenza B virus, is a promising drug candidate. Understanding the anatomic behavior of PB2cap upon ligand binding will aid in the developmen ...[more]