Repeat protein architectures predicted by a continuum representation of fold space.
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ABSTRACT:
SUBMITTER: Hausrath AC
PROVIDER: S-EPMC2242468 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Publications
Repeat protein architectures predicted by a continuum representation of fold space.
Hausrath Andrew C AC Goriely Alain A
Protein science : a publication of the Protein Society 20060307 4
It is an open question whether nature has utilized all possible protein folds. For a simple protein architecture, the helical repeats, we report a method to address this question based on a mapping between the set of repetitive curves and a space of parameters specifying the curve. The exploration of the parameter space for a particular architecture enables a systematic exploration of the fold space for that protein architecture. In a planar subspace of the parameter space of helical repeats we ...[more]
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