Clustering tendency in the protein fold space.
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ABSTRACT:
SUBMITTER: Carugo O
PROVIDER: S-EPMC2951670 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Several non-redundant ensembles of protein three-dimensional structures were analyzed in order to estimate their natural clustering tendency by means of the Cox-Lewis coefficient. It was observed that, despite proteins tend to aggregate into different and well separated groups, some overlap between different clusters occurs. This suggests that classifications bases only on structural data cannot allow a systematic classification of proteins. Additional information are in particular needed in ord ...[more]
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