The role of DNA twist in the packaging of viral genomes.
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ABSTRACT:
SUBMITTER: Rollins GC
PROVIDER: S-EPMC2242773 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Publications
The role of DNA twist in the packaging of viral genomes.
Rollins Geoffrey C GC Petrov Anton S AS Harvey Stephen C SC
Biophysical journal 20080111 5
We performed molecular dynamics simulations of the genome packaging of bacteriophage P4 using two coarse-grained models of DNA. The first model, 1DNA6 (one pseudo-atom per six DNA basepairs), represents DNA as a string of beads, for which DNA torsions are undefined. The second model, 3DNA6 (three pseudo-atoms per six DNA basepairs), represents DNA as a series of base planes with torsions defined by the angles between successive planes. Bacteriophage P4 was packaged with 1DNA6, 3DNA6 in a torsion ...[more]
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