Ontology highlight
ABSTRACT:
SUBMITTER: Talloczy Z
PROVIDER: S-EPMC2242831 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Tallóczy Zsolt Z Martinez Jose J Joset Danielle D Ray Yonaton Y Gácser Attila A Toussi Sima S Mizushima Noboru N Nosanchuk Joshua D JD Goldstein Harris H Loike John J Sulzer David D Santambrogio Laura L
PLoS pathogens 20080201 2
Methamphetamine (Meth) is abused by over 35 million people worldwide. Chronic Meth abuse may be particularly devastating in individuals who engage in unprotected sex with multiple partners because it is associated with a 2-fold higher risk for obtaining HIV and associated secondary infections. We report the first specific evidence that Meth at pharmacological concentrations exerts a direct immunosuppressive effect on dendritic cells and macrophages. As a weak base, Meth collapses the pH gradient ...[more]