Ontology highlight
ABSTRACT:
SUBMITTER: Vigneron N
PROVIDER: S-EPMC6457910 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Vigneron Nathalie N Ferrari Violette V Van den Eynde Benoît J BJ Cresswell Peter P Leonhardt Ralf M RM
Journal of immunology (Baltimore, Md. : 1950) 20180822 7
Cancer immunotherapy has been flourishing in recent years with remarkable clinical success. But as more patients are treated, a shadow is emerging that has haunted other cancer therapies: tumors develop resistance. Resistance is often caused by defects in the MHC class I Ag presentation pathway critical for CD8 T cell-mediated tumor clearance. TAP and tapasin, both key players in the pathway, are frequently downregulated in human cancers, correlating with poor patient survival. Reduced dependenc ...[more]