Ontology highlight
ABSTRACT:
SUBMITTER: Kursula P
PROVIDER: S-EPMC2242944 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Kursula Petri P Flodin Susanne S Ehn Maria M Hammarström Martin M Schüler Herwig H Nordlund Pär P Stenmark Pål P
Acta crystallographica. Section F, Structural biology and crystallization communications 20060610 Pt 7
Cytidine triphosphate synthetase (CTPS) is a key enzyme in nucleic acid and phospholipid biosynthesis and its activity is increased in certain human cancers, making it a promising drug target. The crystal structure of the synthetase domain of human CTPS, which represents the first structure of a CTPS from an eukaryote, has been determined. The structure is homotetrameric and each active site is formed by three different subunits. Sulfate ions bound to the active sites indicate the positions of p ...[more]