Ontology highlight
ABSTRACT:
SUBMITTER: Hallstrom TC
PROVIDER: S-EPMC2243238 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Hallstrom Timothy C TC Mori Seiichi S Nevins Joseph R JR
Cancer cell 20080101 1
The Rb/E2F pathway regulates the expression of genes essential for cell proliferation but that also trigger apoptosis. During normal proliferation, PI3K/Akt signaling blocks E2F1-induced apoptosis, thus serving to balance proliferation and death. We now identify a subset of E2F1 target genes that are specifically repressed by PI3K/Akt signaling, thus distinguishing the E2F1 proliferative or apoptotic function. RNAi-mediated inhibition of several of these PI3K-repressed E2F1 target genes, includi ...[more]