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An E2F1-Dependent Gene Expression Program That Determines the Balance Between Proliferation and Cell Death

ABSTRACT: E2F1 has been shown to induce both proliferation and apoptosis. We now show that PI3K/Akt signaling regulates the balance of these events by specifically blocking expression of genes in the E2F1 apoptotic program but not the proliferative program. Keywords: PI3K dependent modulation of E2F1 gene expression measured by Affymetrix gene expression analysis

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE9496 | GEO | 2007/11/02

SECONDARY ACCESSION(S): PRJNA103283

REPOSITORIES: GEO

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Transcription profiling of rat REF52 cells reveals an E2F1-dependent gene expression program that determines the balance between proliferation and cell death

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