Ontology highlight
ABSTRACT:
SUBMITTER: Zhuravleva MA
PROVIDER: S-EPMC2245879 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Zhuravleva Marina A MA Trandem Kathryn K Sun Peter D PD
Journal of molecular biology 20071011 2
Sialic acid (Sia) Ig-like binding lectins are important mediators of recognition and signaling events among myeloid cells. To investigate the molecular mechanism underlying sialic acid Ig-like lectin (Siglec) functions, we determined the crystal structure of the two N-terminal extracellular domains of human myeloid cell inhibitory receptor Siglec-5 (CD170) and its complexes with two sialylated carbohydrates. The native structure revealed an unusual conformation of the CC' ligand specificity loop ...[more]