Ontology highlight
ABSTRACT:
SUBMITTER: Wilkinson M
PROVIDER: S-EPMC4614115 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Wilkinson Martin M Wigley Dale B DB
Cell cycle (Georgetown, Tex.) 20140101 18
AddAB and RecBCD-type helicase-nuclease complexes control the first stage of bacterial homologous recombination (HR) - the resection of double strand DNA breaks. A switch in the activities of the complexes to initiate repair by HR is regulated by a short, species-specific DNA sequence known as a Crossover Hotspot Instigator (Chi) site. It has been shown that, upon encountering Chi, AddAB and RecBCD pause translocation before resuming at a reduced rate. Recently, the structure of B.subtilis AddAB ...[more]