Ontology highlight
ABSTRACT:
SUBMITTER: Weickert CS
PROVIDER: S-EPMC2246024 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Weickert Cynthia Shannon CS Rothmond Debora A DA Hyde Thomas M TM Kleinman Joel E JE Straub Richard E RE
Schizophrenia research 20071024 1-3
Genetic and molecular studies indicate that dysbindin-1 plays a role in the pathophysiology of schizophrenia. We examined dysbindin-1 mRNA in the hippocampal formation of patients with schizophrenia and found reduced expression in dentate granule and polymorph cells and in hippocampal field CA3, but not in CA1. Furthermore, there were positive correlations between dysbindin-1 mRNA and expression of synaptic markers known to be reduced in schizophrenia. Our results indicate that previously report ...[more]