A new computational approach to analyze human protein complexes and predict novel protein interactions.
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ABSTRACT:
SUBMITTER: Zanivan S
PROVIDER: S-EPMC2246258 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Publications
A new computational approach to analyze human protein complexes and predict novel protein interactions.
Zanivan Sara S Cascone Ilaria I Peyron Chiara C Molineris Ivan I Marchio Serena S Caselle Michele M Bussolino Federico F
Genome biology 20070101 12
We propose a new approach to identify interacting proteins based on gene expression data. By using hypergeometric distribution and extensive Monte-Carlo simulations, we demonstrate that looking at synchronous expression peaks in a single time interval is a high sensitivity approach to detect co-regulation among interacting proteins. Combining gene expression and Gene Ontology similarity analyses enabled the extraction of novel interactions from microarray datasets. Applying this approach to p21- ...[more]
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