Computational large-scale mapping of protein-protein interactions using structural complexes.
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ABSTRACT:
SUBMITTER: Shoemaker B
PROVIDER: S-EPMC3920302 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Computational large-scale mapping of protein-protein interactions using structural complexes.
Shoemaker Benjamin B Wuchty Stefan S Panchenko Anna R AR
Current protocols in protein science 20130924
Although the identification of protein interactions by high-throughput methods progresses at a fast pace, "interactome" datasets still suffer from high rates of false positives and low coverage. To map the interactome of any organism, this unit presents a computational framework to predict protein-protein or gene-gene interactions utilizing experimentally determined evidence of structural complexes, atomic details of binding interfaces and evolutionary conservation. ...[more]
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