Ontology highlight
ABSTRACT:
SUBMITTER: Kawa S
PROVIDER: S-EPMC2249926 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Kawa Shigeyuki S Kitahara Kei K Hamano Hideaki H Ozaki Yayoi Y Arakura Norikazu N Yoshizawa Kaname K Umemura Takeji T Ota Masao M Mizoguchi Sadaaki S Shimozuru Yasunori Y Bahram Seiamak S
PloS one 20080220 2
Well over six decades since its first description, the Rheumatoid Factor (RF)-autoantibodies recognizing Fc (constant) portion of IgG through their own Fab (antigen binding variable segments)-is believed to have come of age. Autoimmune pancreatitis is a unique form of pancreatitis, biologically characterized by an elevated serum IgG4 concentration. Given the fact that IgG4 myeloma proteins can act as RF, we initially hypothesized that IgG4 in autoimmune pancreatitis might do likewise, hence pote ...[more]