Ontology highlight
ABSTRACT:
SUBMITTER: Martin DJ
PROVIDER: S-EPMC3133826 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Martin Douglas J DJ Ramirez-Alvarado Marina M
Biophysical chemistry 20110518 1
Amyloid formation occurs when a precursor protein misfolds and aggregates, forming a fibril nucleus that serves as a template for fibril growth. Glycosaminoglycans are highly charged polymers known to associate with tissue amyloid deposits that have been shown to accelerate amyloidogenesis in vitro. We studied two immunoglobulin light chain variable domains from light chain amyloidosis patients with 90% sequence identity, analyzing their fibril formation kinetics and binding properties with diff ...[more]