Ontology highlight
ABSTRACT:
SUBMITTER: Livesay DR
PROVIDER: S-EPMC2253277 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Livesay Dennis R DR La David D
Protein science : a publication of the Protein Society 20050501 5
Conservation of function is the basic tenet of protein evolution. Conservation of key electrostatic properties is a frequently employed mechanism that leads to conserved function. In a previous report, we identified several conserved electrostatic properties in four protein families and one functionally diverse enzyme superfamily. In this report, we demonstrate the evolutionary and catalytic importance of electrostatic networks in three ubiquitous metabolic enzymes: triosephosphate isomerase, en ...[more]