Ontology highlight
ABSTRACT:
SUBMITTER: Delprato A
PROVIDER: S-EPMC2254184 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Delprato Anna A Lambright David G DG
Nature structural & molecular biology 20070422 5
RABEX-5 and other exchange factors with VPS9 domains regulate endocytic trafficking through activation of the Rab family GTPases RAB5, RAB21 and RAB22. Here we report the crystal structure of the RABEX-5 catalytic core in complex with nucleotide-free RAB21, a key intermediate in the exchange reaction pathway. The structure reveals how VPS9 domain exchange factors recognize Rab GTPase substrates, accelerate GDP release and stabilize the nucleotide-free conformation. We further identify an autoinh ...[more]