Ontology highlight
ABSTRACT:
SUBMITTER: Smith TM
PROVIDER: S-EPMC2254480 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Smith Thomas M TM Kirley Terence L TL
Purinergic signalling 20060601 2
It has long been known that the salivary glands of hematophagous (blood-feeding) arthropods secrete soluble apyrases, which are potent nucleotide hydrolyzing enzymes capable of hydrolyzing extracellular ATP and ADP, the latter being a major agonist contributing to platelet aggregation. Only recently, however, has the identification of proteins homologous to these apyrases been reported in non-blood-feeding organisms such as rodents and humans. In this review, we present an overview of the divers ...[more]