Ontology highlight
ABSTRACT:
SUBMITTER: Whiteley AT
PROVIDER: S-EPMC6544370 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Whiteley Aaron T AT Eaglesham James B JB de Oliveira Mann Carina C CC Morehouse Benjamin R BR Lowey Brianna B Nieminen Eric A EA Danilchanka Olga O King David S DS Lee Amy S Y ASY Mekalanos John J JJ Kranzusch Philip J PJ
Nature 20190220 7747
Cyclic dinucleotides (CDNs) have central roles in bacterial homeostasis and virulence by acting as nucleotide second messengers. Bacterial CDNs also elicit immune responses during infection when they are detected by pattern-recognition receptors in animal cells. Here we perform a systematic biochemical screen for bacterial signalling nucleotides and discover a large family of cGAS/DncV-like nucleotidyltransferases (CD-NTases) that use both purine and pyrimidine nucleotides to synthesize a divers ...[more]