Ontology highlight
ABSTRACT:
SUBMITTER: Tober J
PROVIDER: S-EPMC2254541 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Tober Joanna J McGrath Kathleen E KE Palis James J
Blood 20080103 5
Hematopoiesis initiates within the yolk sac of mammalian embryos in overlapping primitive and definitive waves, each containing erythroid and megakaryocyte progenitors. c-myb-null mouse fetuses lack definitive erythrocytes but contain primitive erythroblasts and hepatic megakaryocytes. However, it is unclear if c-myb-null embryos harbor definitive erythroid or any megakaryocyte progenitors. We determined that c-myb was not expressed in primitive erythroid precursors and that c-myb-null embryos h ...[more]