Ontology highlight
ABSTRACT:
SUBMITTER: Lee LK
PROVIDER: S-EPMC6940422 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Lee Lydia K LK Ghorbanian Yasamine Y Wang Wenyuan W Wang Yanling Y Kim Yeon Joo YJ Weissman Irving L IL Inlay Matthew A MA Mikkola Hanna K A HKA
Cell reports 20161101 9
The contribution of the different waves and sites of developmental hematopoiesis to fetal and adult blood production remains unclear. Here, we identify lymphatic vessel endothelial hyaluronan receptor-1 (LYVE1) as a marker of yolk sac (YS) endothelium and definitive hematopoietic stem and progenitor cells (HSPCs). Endothelium in mid-gestation YS and vitelline vessels, but not the dorsal aorta and placenta, were labeled by Lyve1-Cre. Most YS HSPCs and erythro-myeloid progenitors were Lyve1-Cre li ...[more]