Ontology highlight
ABSTRACT:
SUBMITTER: Kainz E
PROVIDER: S-EPMC2258586 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Kainz Elke E Gallmetzer Andreas A Hatzl Christian C Nett Juergen H JH Li Huijuan H Schinko Thorsten T Pachlinger Robert R Berger Harald H Reyes-Dominguez Yazmid Y Bernreiter Andreas A Gerngross Tillmann T Wildt Stefan S Strauss Joseph J
Applied and environmental microbiology 20071214 4
The production by filamentous fungi of therapeutic glycoproteins intended for use in mammals is held back by the inherent difference in protein N-glycosylation and by the inability of the fungal cell to modify proteins with mammalian glycosylation structures. Here, we report protein N-glycan engineering in two Aspergillus species. We functionally expressed in the fungal hosts heterologous chimeric fusion proteins containing different localization peptides and catalytic domains. This strategy all ...[more]