Ontology highlight
ABSTRACT:
SUBMITTER: Katpally U
PROVIDER: S-EPMC2258928 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Katpally Umesh U Wobus Christiane E CE Dryden Kelly K Virgin Herbert W HW Smith Thomas J TJ
Journal of virology 20071219 5
Noroviruses (family Caliciviridae) are the major cause of epidemic nonbacterial gastroenteritis in humans, but the mechanism of antibody neutralization is unknown and no structure of an infectious virion has been reported. Murine norovirus (MNV) is the only norovirus that can be grown in tissue culture, studied in an animal model, and reverse engineered via an infectious clone and to which neutralizing antibodies have been isolated. Presented here are the cryoelectron microscopy structures of an ...[more]