Ontology highlight
ABSTRACT:
SUBMITTER: Contreras JE
PROVIDER: S-EPMC2265121 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Contreras Jorge E JE Srikumar Deepa D Holmgren Miguel M
Proceedings of the National Academy of Sciences of the United States of America 20080220 9
By opening and closing the permeation pathway (gating) in response to cGMP binding, cyclic nucleotide-gated (CNG) channels serve key roles in the transduction of visual and olfactory signals. Compiling evidence suggests that the activation gate in CNG channels is not located at the intracellular end of pore, as it has been established for voltage-activated potassium (K(V)) channels. Here, we show that ion permeation in CNG channels is tightly regulated at the selectivity filter. By scanning the ...[more]