Ontology highlight
ABSTRACT:
SUBMITTER: Mazzolini M
PROVIDER: S-EPMC5758780 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Mazzolini Monica M Arcangeletti Manuel M Marchesi Arin A Napolitano Luisa M R LMR Grosa Debora D Maity Sourav S Anselmi Claudio C Torre Vincent V
Scientific reports 20180108 1
Cyclic nucleotide-gated (CNG) channels mediate transduction in several sensory neurons. These channels use the free energy of CNs' binding to open the pore, a process referred to as gating. CNG channels belong to the superfamily of voltage-gated channels, where the motion of the α-helix S6 controls gating in most of its members. To date, only the open, cGMP-bound, structure of a CNG channel has been determined at atomic resolution, which is inadequate to determine the molecular events underlying ...[more]