Ontology highlight
ABSTRACT:
SUBMITTER: Sugarbaker DJ
PROVIDER: S-EPMC2265129 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Sugarbaker David J DJ Richards William G WG Gordon Gavin J GJ Dong Lingsheng L De Rienzo Assunta A Maulik Gautam G Glickman Jonathan N JN Chirieac Lucian R LR Hartman Mor-Li ML Taillon Bruce E BE Du Lei L Bouffard Pascal P Kingsmore Stephen F SF Kingsmore Stephen F SF Miller Neil A NA Farmer Andrew D AD Jensen Roderick V RV Gullans Steven R SR Bueno Raphael R
Proceedings of the National Academy of Sciences of the United States of America 20080226 9
Cancers arise by the gradual accumulation of mutations in multiple genes. We now use shotgun pyrosequencing to characterize RNA mutations and expression levels unique to malignant pleural mesotheliomas (MPMs) and not present in control tissues. On average, 266 Mb of cDNA were sequenced from each of four MPMs, from a control pulmonary adenocarcinoma (ADCA), and from normal lung tissue. Previously observed differences in MPM RNA expression levels were confirmed. Point mutations were identified by ...[more]