Heterogeneity in Malignant Pleural Mesothelioma.
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ABSTRACT:
SUBMITTER: Oehl K
PROVIDER: S-EPMC6032160 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Heterogeneity in Malignant Pleural Mesothelioma.
Oehl Kathrin K Vrugt Bart B Opitz Isabelle I Meerang Mayura M
International journal of molecular sciences 20180530 6
Despite advances in malignant pleural mesothelioma therapy, life expectancy of affected patients remains short. The limited efficiency of treatment options is mainly caused by inter- and intra-tumor heterogeneity of mesotheliomas. This diversity can be observed at the morphological and molecular levels. Molecular analyses reveal a high heterogeneity (i) between patients; (ii) within different areas of a given tumor in terms of different clonal compositions; and (iii) during treatment over time. ...[more]
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