Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.
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ABSTRACT:
SUBMITTER: Chopera DR
PROVIDER: S-EPMC2265427 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Publications
Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.
Chopera Denis R DR Woodman Zenda Z Mlisana Koleka K Mlotshwa Mandla M Martin Darren P DP Seoighe Cathal C Treurnicht Florette F de Rosa Debra Assis DA Hide Winston W Karim Salim Abdool SA Gray Clive M CM Williamson Carolyn C
PLoS pathogens 20080321 3
One of the most important genetic factors known to affect the rate of disease progression in HIV-infected individuals is the genotype at the Class I Human Leukocyte Antigen (HLA) locus, which determines the HIV peptides targeted by cytotoxic T-lymphocytes (CTLs). Individuals with HLA-B*57 or B*5801 alleles, for example, target functionally important parts of the Gag protein. Mutants that escape these CTL responses may have lower fitness than the wild-type and can be associated with slower diseas ...[more]
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