Ontology highlight
ABSTRACT:
SUBMITTER: Rozovski U
PROVIDER: S-EPMC6864283 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Rozovski Uri U Harris David M DM Li Ping P Liu Zhiming Z Jain Preetesh P Ferrajoli Alessandra A Burger Jan A JA Bose Prithviraj P Thompson Phillip A PA Jain Nitin N Wierda William G WG Uziel Orit O Keating Michael J MJ Estrov Zeev Z
Journal of immunology (Baltimore, Md. : 1950) 20191023 11
The wingless and integration site growth factor-5a (Wnt5a) is a ligand of the receptor tyrosine kinase-like orphan receptor-1 (ROR1). Because both Wnt5a and ROR1 are expressed in circulating chronic lymphocytic leukemia (CLL) cells, and because in other cell types, STAT3, which is constitutively activated in CLL, induces Wnt5a signaling, we wondered whether STAT3 induces the expression of Wnt5a in CLL cells. Sequence analysis detected four putative STAT3 binding sites in close proximity to the W ...[more]