Ontology highlight
ABSTRACT:
SUBMITTER: Zou L
PROVIDER: S-EPMC2265476 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Zou Lihua L Sriswasdi Sira S Ross Brian B Missiuro Patrycja V PV Liu Jun J Ge Hui H
PLoS computational biology 20080229 2
Pleiotropy refers to the phenomenon in which a single gene controls several distinct, and seemingly unrelated, phenotypic effects. We use C. elegans early embryogenesis as a model to conduct systematic studies of pleiotropy. We analyze high-throughput RNA interference (RNAi) data from C. elegans and identify "phenotypic signatures", which are sets of cellular defects indicative of certain biological functions. By matching phenotypic profiles to our identified signatures, we assign genes with com ...[more]