A protein domain-based interactome network for C. elegans early embryogenesis.
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ABSTRACT:
SUBMITTER: Boxem M
PROVIDER: S-EPMC2596478 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
A protein domain-based interactome network for C. elegans early embryogenesis.
Boxem Mike M Maliga Zoltan Z Klitgord Niels N Li Na N Lemmens Irma I Mana Miyeko M de Lichtervelde Lorenzo L Mul Joram D JD van de Peut Diederik D Devos Maxime M Simonis Nicolas N Yildirim Muhammed A MA Cokol Murat M Kao Huey-Ling HL de Smet Anne-Sophie AS Wang Haidong H Schlaitz Anne-Lore AL Hao Tong T Milstein Stuart S Fan Changyu C Tipsword Mike M Drew Kevin K Galli Matilde M Rhrissorrakrai Kahn K Drechsel David D Koller Daphne D Roth Frederick P FP Iakoucheva Lilia M LM Dunker A Keith AK Bonneau Richard R Gunsalus Kristin C KC Hill David E DE Piano Fabio F Tavernier Jan J van den Heuvel Sander S Hyman Anthony A AA Vidal Marc M
Cell 20080801 3
Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or "interactome" networks have largely ignored this modular organization of proteins. We developed an experimental strategy to efficiently identify interaction domains and generated a domain-based interactome network for proteins involved in C. elegans early-embryonic cell divisions. Minimal interacting regions were identified for over 200 prote ...[more]
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