Ontology highlight
ABSTRACT:
SUBMITTER: Fielding AB
PROVIDER: S-EPMC2265580 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Fielding Andrew B AB Dobreva Iveta I McDonald Paul C PC Foster Leonard J LJ Dedhar Shoukat S
The Journal of cell biology 20080218 4
Integrin-linked kinase (ILK) is a serine-threonine kinase and scaffold protein with well defined roles in focal adhesions in integrin-mediated cell adhesion, spreading, migration, and signaling. Using mass spectrometry-based proteomic approaches, we identify centrosomal and mitotic spindle proteins as interactors of ILK. alpha- and beta-tubulin, ch-TOG (XMAP215), and RUVBL1 associate with ILK and colocalize with it to mitotic centrosomes. Inhibition of ILK activity or expression induces profound ...[more]