Ontology highlight
ABSTRACT:
SUBMITTER: Jin G
PROVIDER: S-EPMC2266064 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Jin Guangzhi G Kubo Hiroshi H Kashiba Misato M Horinouchi Ryo R Hasegawa Makoto M Suzuki Masaru M Sagawa Tomofumi T Oizumi Mikiko M Fujisawa Akio A Tsukamoto Hideo H Yoshimura Shinichi S Yamamoto Yorihiro Y
Journal of clinical biochemistry and nutrition 20080301 2
Coenzyme Q10 (CoQ10) is essential for ATP production in the mitochondria, and is an important antioxidant in every biomembrane and lipoprotein. Due to its hydrophobicity, a binding and transfer protein for CoQ10 is plausible, but none have yet been isolated and characterized. Here we purified a CoQ10-binding protein from human urine and identified it to be saposin B, a housekeeping protein necessary for sphingolipid hydrolysis in lysosomes. We confirmed that cellular saposin B binds CoQ10 in hum ...[more]