Ontology highlight
ABSTRACT:
SUBMITTER: Liu G
PROVIDER: S-EPMC2266630 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Liu Guofa G Beggs Hilary H Jürgensen Claudia C Park Hwan-Tae HT Tang Hao H Gorski Jessica J Jones Kevin R KR Reichardt Louis F LF Wu Jane J Rao Yi Y
Nature neuroscience 20041017 11
Although netrins are an important family of neuronal guidance proteins, intracellular mechanisms that mediate netrin function are not well understood. Here we show that netrin-1 induces tyrosine phosphorylation of proteins including focal adhesion kinase (FAK) and the Src family kinase Fyn. Blockers of Src family kinases inhibited FAK phosphorylation and axon outgrowth and attraction by netrin. Dominant-negative FAK and Fyn mutants inhibited the attractive turning response to netrin. Axon outgro ...[more]