Ontology highlight
ABSTRACT:
SUBMITTER: Wu JC
PROVIDER: S-EPMC4683442 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Wu Jui-Chung JC Chen Yu-Chen YC Kuo Chih-Ting CT Wenshin Yu Helen H Chen Yin-Quan YQ Chiou Arthur A Kuo Jean-Cheng JC
Scientific reports 20151218
Directed cell migration requires dynamical control of the protein complex within focal adhesions (FAs) and this control is regulated by signaling events involving tyrosine phosphorylation. We screened the SH2 domains present in tyrosine-specific kinases and phosphatases found within FAs, including SRC, SHP1 and SHP2, and examined whether these enzymes transiently target FAs via their SH2 domains. We found that the SRC_SH2 domain and the SHP2_N-SH2 domain are associated with FAs, but only the SRC ...[more]