Ontology highlight
ABSTRACT:
SUBMITTER: Sandilands E
PROVIDER: S-EPMC2267225 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
EMBO reports 20071102 12
The non-receptor tyrosine kinase Src is recruited to activated fibroblast growth factor receptor (FGFR) complexes through the adaptor protein factor receptor substrate 2 (FRS2). Here, we show that Src kinase activity has a crucial role in the regulation of FGFR1 signalling dynamics. Following receptor activation by ligand binding, activated Src is colocalized with activated FGFR1 at the plasma membrane. This localization requires both active Src and FGFR1 kinases, which are inter-dependent. Inte ...[more]