Ontology highlight
ABSTRACT:
SUBMITTER: Fiori JL
PROVIDER: S-EPMC2689793 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Fiori Jennifer L JL Zhu Tie-Nian TN O'Connell Michael P MP O'Connell Michael P MP Hoek Keith S KS Indig Fred E FE Frank Brittany P BP Morris Christa C Kole Sutapa S Hasskamp Joanne J Elias George G Weeraratna Ashani T AT Bernier Michel M
Endocrinology 20090212 6
The actin-binding protein filamin A (FLNa) affects the intracellular trafficking of various classes of receptors and has a potential role in oncogenesis. However, it is unclear whether FLNa regulates the signaling capacity and/or down-regulation of the activated epidermal growth factor receptor (EGFR). Here it is shown that partial knockdown of FLNa gene expression blocked ligand-induced EGFR responses in metastatic human melanomas. To gain greater insights into the role of FLNa in EGFR activati ...[more]