Ontology highlight
ABSTRACT:
SUBMITTER: Braun S
PROVIDER: S-EPMC2267232 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Braun Sigurd S Jentsch Stefan S
EMBO reports 20071109 12
Endoplasmic reticulum (ER)-associated degradation (ERAD) is a specialized activity of the ubiquitin-proteasome system that is involved in clearing the ER of aberrant proteins and regulating the levels of specific ER-resident proteins. Here we show that the yeast ER-SNARE Ufe1, a syntaxin (Qa-SNARE) involved in ER membrane fusion and retrograde transport from the Golgi to the ER, is prone to degradation by an ERAD-like mechanism. Notably, Ufe1 is protected against degradation through binding to S ...[more]