Ontology highlight
ABSTRACT:
SUBMITTER: Prusty AB
PROVIDER: S-EPMC5551706 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Prusty Archana Bairavasundaram AB Meduri Rajyalakshmi R Prusty Bhupesh Kumar BK Vanselow Jens J Schlosser Andreas A Fischer Utz U
The Journal of cell biology 20170621 8
Specialized assembly factors facilitate the formation of many macromolecular complexes in vivo. The formation of Sm core structures of spliceosomal U-rich small nuclear ribonucleoprotein particles (UsnRNPs) requires assembly factors united in protein arginine methyltransferase 5 (PRMT5) and survival motor neuron (SMN) complexes. We demonstrate that perturbations of this assembly machinery trigger complex cellular responses that prevent aggregation of unassembled Sm proteins. Inactivation of the ...[more]