Ontology highlight
ABSTRACT:
SUBMITTER: Pearson KJ
PROVIDER: S-EPMC2268135 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Pearson Kevin J KJ Lewis Kaitlyn N KN Price Nathan L NL Chang Joy W JW Perez Evelyn E Cascajo Maria Victoria MV Tamashiro Kellie L KL Poosala Suresh S Csiszar Anna A Ungvari Zoltan Z Kensler Thomas W TW Yamamoto Masayuki M Egan Josephine M JM Longo Dan L DL Ingram Donald K DK Navas Placido P de Cabo Rafael R de Cabo Rafael R
Proceedings of the National Academy of Sciences of the United States of America 20080219 7
Caloric restriction (CR) is the most potent intervention known to both protect against carcinogenesis and extend lifespan in laboratory animals. A variety of anticarcinogens and CR mimetics induce and activate the NF-E2-related factor 2 (Nrf2) pathway. Nrf2, in turn, induces a number of antioxidative and carcinogen-detoxifying enzymes. Thus, Nrf2 offers a promising target for anticarcinogenesis and antiaging interventions. We used Nrf2-disrupted (KO) mice to examine its role on the biological ef ...[more]