Ontology highlight
ABSTRACT:
SUBMITTER: Someya S
PROVIDER: S-EPMC3018849 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Someya Shinichi S Yu Wei W Hallows William C WC Xu Jinze J Vann James M JM Leeuwenburgh Christiaan C Tanokura Masaru M Denu John M JM Prolla Tomas A TA
Cell 20101101 5
Caloric restriction (CR) extends the life span and health span of a variety of species and slows the progression of age-related hearing loss (AHL), a common age-related disorder associated with oxidative stress. Here, we report that CR reduces oxidative DNA damage in multiple tissues and prevents AHL in wild-type mice but fails to modify these phenotypes in mice lacking the mitochondrial deacetylase Sirt3, a member of the sirtuin family. In response to CR, Sirt3 directly deacetylates and activat ...[more]