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Candida nivariensis, an emerging pathogenic fungus with multidrug resistance to antifungal agents.

ABSTRACT: In 2005, Candida nivariensis, a yeast species genetically related to Candida glabrata, was described following its isolation from three patients in a single Spanish hospital. Between 2005 and 2006, 16 fungal isolates with phenotypic similarities to C. nivariensis were submitted to the United Kingdom Mycology Reference Laboratory for identification. The strains originated from various clinical specimens, including deep, usually sterile sites, from patients at 12 different hospitals in the United Kingdom. PCR amplification and sequencing of the D1D2 and internal transcribed spacer 1 (ITS1) regions of the nuclear ribosomal gene cassette confirmed that these isolates from the United Kingdom are genetically identical to C. nivariensis. Biochemically, C. glabrata and C. nivariensis are distinguished by their differential abilities to assimilate trehalose. However, in contrast to the original published findings, we found that C. glabrata isolates, but not C. nivariensis isolates, are capable of assimilating this substrate. Antifungal susceptibility tests revealed that C. nivariensis isolates are less susceptible than C. glabrata isolates to itraconazole, fluconazole, and voriconazole and to have significantly higher flucytosine MICs than C. glabrata strains. Finally, C. nivariensis could be rapidly distinguished from the other common pathogenic fungus species by pyrosequencing of the ITS2 region. In the light of these data, we believe that C. nivariensis should be regarded as a clinically important emerging pathogenic fungus.

SUBMITTER: Borman AM

PROVIDER: S-EPMC2268332 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature

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Candida nivariensis, an emerging pathogenic fungus with multidrug resistance to antifungal agents.

Borman Andrew M AM Petch Rebecca R Linton Christopher J CJ Palmer Michael D MD Bridge Paul D PD Johnson Elizabeth M EM

Journal of clinical microbiology 20080116 3

In 2005, Candida nivariensis, a yeast species genetically related to Candida glabrata, was described following its isolation from three patients in a single Spanish hospital. Between 2005 and 2006, 16 fungal isolates with phenotypic similarities to C. nivariensis were submitted to the United Kingdom Mycology Reference Laboratory for identification. The strains originated from various clinical specimens, including deep, usually sterile sites, from patients at 12 different hospitals in the United ...[more]

PMID: 18199788

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Candida nivariensis, an emerging pathogenic fungus with multidrug resistance to antifungal agents.

Publications

Candida nivariensis, an emerging pathogenic fungus with multidrug resistance to antifungal agents.

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