Ontology highlight
ABSTRACT:
SUBMITTER: Colella M
PROVIDER: S-EPMC2268550 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Colella Matilde M Grisan Francesca F Robert Valerie V Turner Jay D JD Thomas Andrew P AP Pozzan Tullio T
Proceedings of the National Academy of Sciences of the United States of America 20080219 8
The role of Ca(2+) signaling in triggering hypertrophy was investigated in neonatal rat cardiomyocytes in vitro. We show that an increase in cell size and sarcomere reorganization were elicited by receptor agonists such as Angiotensin II, aldosterone, and norepinephrine and by a small rise in medium KCl concentration, a treatment devoid of direct effects on receptor functions. All these treatments increased the frequency of spontaneous [Ca(2+)] transients, caused nuclear translocation of transfe ...[more]