The Epstein-Barr virus BMRF-2 protein facilitates virus attachment to oral epithelial cells.
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ABSTRACT:
SUBMITTER: Xiao J
PROVIDER: S-EPMC2268893 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
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The Epstein-Barr virus BMRF-2 protein facilitates virus attachment to oral epithelial cells.
Xiao Jianqiao J Palefsky Joel M JM Herrera Rossana R Berline Jennifer J Tugizov Sharof M SM
Virology 20071022 2
We previously reported that BMRF-2, an Epstein-Barr virus (EBV) glycoprotein, binds to beta1 family integrins and is important for EBV infection of polarized oral epithelial cells. To further study the functions of BMRF-2, we constructed a recombinant EBV that lacks BMRF-2 expression by homologous recombination in B95-8 cells. We found that lack of BMRF-2 resulted in about 50% reduction of EBV attachment to oral epithelial cells, but not to B lymphocytes, suggesting that BMRF-2 is critical for E ...[more]
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