A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
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ABSTRACT:
SUBMITTER: van Heel DA
PROVIDER: S-EPMC2274985 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
van Heel David A DA Franke Lude L Hunt Karen A KA Gwilliam Rhian R Zhernakova Alexandra A Inouye Mike M Wapenaar Martin C MC Barnardo Martin C N M MC Bethel Graeme G Holmes Geoffrey K T GK Feighery Con C Jewell Derek D Kelleher Dermot D Kumar Parveen P Travis Simon S Walters Julian R F JR Sanders David S DS Howdle Peter P Swift Jill J Playford Raymond J RJ McLaren William M WM Mearin M Luisa ML Mulder Chris J CJ McManus Ross R McGinnis Ralph R Cardon Lon R LR Deloukas Panos P Wijmenga Cisca C
Nature genetics 20070610 7
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease. ...[more]
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