Ontology highlight
ABSTRACT:
SUBMITTER: Festen EA
PROVIDER: S-EPMC2757103 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Festen E A M EA Goyette P P Scott R R Annese V V Zhernakova A A Lian J J Lefèbvre C C Brant S R SR Cho J H JH Silverberg M S MS Taylor K D KD de Jong D J DJ Stokkers P C PC Mcgovern D D Palmieri O O Achkar J-P JP Xavier R J RJ Daly M J MJ Duerr R H RH Wijmenga C C Weersma R K RK Rioux J D JD
Gut 20090206 6
<h4>Objectives</h4>Genetic susceptibility is known to play a large part in the predisposition to the inflammatory bowel diseases (IBDs) known as Crohn's disease (CD) and ulcerative colitis (UC). The IL2/IL21 locus on 4q27 is known to be a common risk locus for inflammatory disease (shown in coeliac disease, type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus and psoriasis), while the roles that interleukin 2 (IL2) and IL21 play in the immune response also make them attractive can ...[more]