Ontology highlight
ABSTRACT:
SUBMITTER: Ghiaur G
PROVIDER: S-EPMC2275001 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Ghiaur Gabriel G Ferkowicz Michael J MJ Milsom Michael D MD Bailey Jeff J Witte David D Cancelas Jose A JA Yoder Mervin C MC Williams David A DA
Blood 20071214 7
Definitive hematopoietic stem and progenitor cells (HSCs/Ps) originating from the yolk sac and/or para-aorta-splanchno-pleura/aorta-gonad-mesonephros are hypothesized to colonize the fetal liver, but mechanisms involved are poorly defined. The Rac subfamily of Rho GTPases has been shown to play essential roles in HSC/P localization to the bone marrow following transplantation. Here, we study the role of Rac1 in HSC/P migration during ontogeny and seeding of fetal liver. Using a triple-transgenic ...[more]